Making acid–base medicine clear, fast, and free

Our mission

The anion gap is one of the most informative calculations you can perform from a routine metabolic panel — yet it is often taught in a rushed, formula-first way that leaves learners without the context to interpret it at the bedside. Our mission is to change that. We pair accurate, instant calculators with the physiology, mnemonics, and clinical reasoning that turn a single number into an actionable differential diagnosis.

What we offer

The site is a complete topical hub built around the anion gap. It includes:

• 9 interactive calculators — the anion gap, albumin-corrected anion gap, anion gap with potassium, delta gap, delta ratio, urine anion gap, osmolar gap, bicarbonate deficit, and strong ion difference.
• 68+ pages of clinical content covering formulas and derivation, interpretation (high, low, normal-gap acidosis, corrected), acid–base disorders (HAGMA, NAGMA, mixed), causes and mnemonics (MUDPILES, GOLD MARK), special populations, physiology and biochemistry, reference ranges, worked case studies, and FAQs.
• In-text citations and structured data on every page so the content is traceable and discoverable.

Our approach

Everything we publish is evidence-based. Calculations and interpretation are reviewed against reputable clinical references — including StatPearls, Life in the Fast Lane (LITFL), MDCalc, the American Diabetes Association (ADA), and peer-reviewed literature — and we cite our sources so you can verify them. Where references disagree (for example, on normal ranges or mnemonic updates), we present the alternatives transparently.

Every calculation runs entirely in your browser. That means the tools are fast, work offline, and — critically — protect your privacy: the laboratory values you enter never leave your device.

Who we serve

The site is built for a wide audience of learners and practitioners:

• Medical students learning acid–base physiology and preparing for exams;
• Residents and attending physicians who want a fast, reliable bedside reference;
• Nurses, pharmacists, and allied health professionals interpreting metabolic panels;
• Patients who want to better understand their own lab results in partnership with their clinician.

Content quality

Each page follows a consistent structure designed for clarity and discoverability: a plain-language definition, the underlying formula and derivation, interpretation tables, clinical pearls, and related tools. Every page includes structured data for AI search, features in-text citations, and follows semantic SEO best practices so the right answer surfaces for the right query.

Privacy first

There are no accounts, no sign-ups, and no data collection from our calculators. All math happens locally in your browser. The only information we gather is anonymized, aggregate traffic analytics that helps us improve the site. Read the details in our Privacy Policy.

Get in touch

Have a question, a correction, or a suggestion for new content? We would love to hear from you. Visit our Contact page or email info@anion-gap-calculation.com. You can also explore the full hub of calculators and guides from the All Tools section.